Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages
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- 作者：Evanna L. Mills1 ; 12 ; 13 ; Beth Kelly1 ; 12 ; Angela Logan2 ; Ana S.H. Costa3 ; Mukund Varma4 ; Clare E. Bryant6 ; Panagiotis Tourlomousis6 ; J. Henry M. Dä ; britz7 ; Eyal Gottlieb7 ; Isabel Latorre4 ; Siné ; ad C. Corr8 ; Gavin McManus1 ; Dylan Ryan1 ; Howard T. Jacobs9 ; 10 ; Marten Szibor9 ; 10 ; 11 ; Ramnik J. Xavier4 ; 5 ; Thomas Braun11 ; Christian Frezza3 ; Michael P. Murphy2 ; mpm@mrc-mbu.cam.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Luke A. O&rsquo ; Neill1 ; 14 ; laoneill@tcd.ie" class="auth_mail" title="E-mail the corresponding author
- 关键词：immunometabolism ; succinate ; succinate dehydrogenase ; reverse electron transport ; toll-like receptors ; innate immunity ; macrophage
- 刊名：Cell
- 出版年：2016
- 出版时间：6 October 2016
- 年：2016
- 卷：167
- 期：2
- 页码：457-470.e13
- 全文大小：5857 K
文摘
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LPS induces mitochondrial repurposing from ATP synthesis to ROS production
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Oxidation of succinate and mitochondrial hyperpolarization drive ROS production
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Blocking LPS-induced ROS production or hyperpolarization inhibits IL-1β
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SDH is critical for the inflammatory response