18F-FLT PET imaging of cellular proliferation in pancreatic cancer
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- 作者：Angela Lamarcaa ; angela.lamarca@christie.nhs.uk" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Marie-Claude AsselinbAuthor Vitae ; Prakash ManoharancAuthor Vitae ; Mairé ; ad G. McNamaraa ; dAuthor Vitae ; Ioannis TrigonisbAuthor Vitae ; Richard HubneraAuthor Vitae ; Azeem Saleemb ; eAuthor Vitae ; Juan W. Vallea ; d ; juan.valle@manchester.ac.uk" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：Cancer ; 18F-FLT PET ; Thymidine ; Proliferation ; Pancreatic cancer ; Adenocarcinoma
- 刊名：Critical Reviews in Oncology and Hematology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：99
- 期：Complete
- 页码：158-169
- 全文大小：1546 K
文摘
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There is a potential for integrating other imaging modalities in the management of pancreatic cancer.
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Standard uptake values from 18F-FLT PET images have been shown to correlate with cellular proliferation in some malignancies.
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18F-FLT PET in GI malignancies is limited by high physiologic radiotracer uptake in surrounding normal tissues and liver.
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18F-FLT PET has higher specificity but lower sensitivity compared to 18F-FDG PET for measurement of cellular proliferation.
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Dynamic imaging with 18F-FLT PET allows an improved understanding of treatment effects and detection of liver metastases.