Outbreak of Multidrug-resistant Tuberculosis in Two Secondary Schools

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• 作者：Luis Miravet Sorribes^a ; ^{miravet_lui@gva.es" class="auth_mail" title="E-mail the corresponding author} ; Alberto Arnedo Pena^b ; ^d ; Juan B. Bellido Blasco^b ; ^d ; Mar&iacute ; a Angeles Romeu Garc&iacute ; a^b ; Mar&iacute ; a Gil Fortuñ ; o^c ; Patricia Garc&iacute ; a Sidro^a ; Pascual Corté ; s Miró ; ^a
• 关键词：Multidrug-resistant tuberculosi ; Outbreak ; Schools ; Spoligotyping
• 刊名：Archivos de Bronconeumología (English Edition)
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：52
• 期：2
• 页码：70-75
• 全文大小：658 K

文摘

To describe an outbreak of multidrug-resistant tuberculosis (MDR-TB) in two schools.

Methods

This was a prospective, observational study of an outbreak of MDR-TB in 2 schools located in the towns of Onda and Nules, in the Spanish province of Castellon, from the moment of detection in November 2008 until November 2014, including patient follow-up and contact tracing.

Results

Five cases of MDR-TB were diagnosed. Overall attack rate was 0.9%, and among the contacts traced, 66 had latent tuberculous infection, with an infection rate of 14.4%. Molecular characterization of the 5 M. tuberculosis isolates was performed by restriction fragment length polymorphism (RFLP) analysis of the IS6110 sequence. In all 5 patients, cultures were negative at 4-month follow-up, showing the efficacy of the treatment given. No recurrence has been reported to date.

Conclusions

In the context of globalization and the increased prevalence of MDR-TB, outbreaks such as the one presented here are only to be expected. Contact tracing, strict follow-up of confirmed cases, the availability of fast diagnostic techniques to avoid treatment delay, and chemoprophylaxis, together with the molecular characterization of strains, are still essential.