Immunoregulatory signal FoxP3, cytokine gene expression and IFN-γ cell responsiveness upon porcine reproductive and respiratory syndrome virus (PRRSV) natural infection
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- 作者：Giulia Ferrarini giulia.ferrarini@studenti.unipr.it" class="auth_mail" title="E-mail the corresponding author ; Paolo Borghetti paolo.borghetti@unipr.it" class="auth_mail" title="E-mail the corresponding author ; Elena De Angelis elena.deangelis@unipr.it" class="auth_mail" title="E-mail the corresponding author ; Luca Ferrari ; luca.ferrari@unipr.it" class="auth_mail" title="E-mail the corresponding author ; Elena Canelli elena.canelli@libero.it" class="auth_mail" title="E-mail the corresponding author ; Alessia Catella alessia.catella@alice.it" class="auth_mail" title="E-mail the corresponding author ; Rosanna Di Lecce rosanna.dilecce@unipr.it" class="auth_mail" title="E-mail the corresponding author ; Paolo Martelli paolo.martelli@unipr.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pig ; Porcine reproductive and respiratory syndrome virus (PRRSV) ; Forkhead box P3 (FoxP3) ; Cytokines ; Interferon-gamma (IFN-γ) secreting cell (SC) responsiveness
- 刊名：Research in Veterinary Science
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：103
- 期：Complete
- 页码：96-102
- 全文大小：769 K
文摘
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Pro-inflammatory cytokine gene expression can be differently modulated by the PRRSV isolate causing infection;
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PRRSV infection can increase FoxP3 gene expression as a marker of Treg activation;
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PRRSV vaccination could maintain FoxP3 lower expression overtime;
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FoxP3 modulation does not appear strictly associated with IL-10 gene expression;
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Treg activation could be a suitable parameter to evaluate the immunomodulatory effect of different PRRSV isolates.