Parathyroid carcinoma and atypical parathyroid neoplasms in MEN1 patients; A clinico-pathologic challenge. The MD Anderson case series and review of the literature
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- 作者：Ioannis Christakisa ; Naifa L. Busaidyb ; Gilbert J. Coteb ; Michelle D. Williamsc ; Samuel M. Hyded ; Angelica M. Silva Figueroaa ; Lily Joy Kwatamporab ; Callisia N. Clarkea ; Wei Qiua ; e ; Jeffrey E. Leea ; Nancy D. Perriera ; nperrier@mdanderson.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hypercalcemia ; Multiple endocrine neoplasia type 1 (MEN 1) ; Parathyroidectomy ; Parathyroid carcinoma ; Neoplasm ; Parathyroid gland ; Primary hyperparathyroidism
- 刊名：International Journal of Surgery
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：31
- 期：Complete
- 页码：10-16
- 全文大小：785 K
文摘
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Parathyroid carcinoma or atypical parathyroid neoplasm can occur Multiple endocrine neoplasia type 1 (MEN1).
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We present 2 cases of parathyroid carcinoma and 1 case of atypical parathyroid neoplasm in a cohort of 291 MEN1 patients.
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The observed genetic mutations in the PC patients were c.703G > A (p.E235K) in exon 4 and c.1378C > T (p.R460X) in exon 10.
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The malignancy potential of parathyroid tumors affects surgical planning for hyperparathyroidism treatment in MEN1 patients.