Antiviral activity of angelicin against gammaherpesviruses

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• 作者：Hye-Jeong Cho ; Seon-Gyeong Jeong ; Ji-Eun Park ; Jin-Ah Han ; Hye-Ri Kang ; Dongho Lee ; Moon Jung Song
• 关键词：Antiviral activity ; EBV ; KSHV ; MHV-68 ; Angelicin ; Furocoumarins
• 刊名：Antiviral Research
• 出版年：October, 2013
• 年：2013
• 卷：100
• 期：1
• 页码：75-83
• 全文大小：1370 K

文摘

Human gammaherpesviruses including Epstein-Barr virus (EBV) and Kaposi鈥檚 sarcoma-associated herpesvirus (KSHV) are important pathogens as they persist in the host and cause various malignancies. However, few antiviral drugs are available to efficiently control gammaherpesvirus replication. Here we identified the antiviral activity of angelicin against murine gammaherpesvirus 68 (MHV-68), genetically and biologically related to human gammaherpesviruses. Angelicin, a furocoumarin naturally occurring tricyclic aromatic compound, efficiently inhibited lytic replication of MHV-68 in a dose-dependent manner following the virus entry. The IC₅₀ of angelicin antiviral activity was estimated to be 28.95 渭M, while the CC₅₀ of angelicin was higher than 2600 渭M. Furthermore, incubation with angelicin efficiently inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lytic replication of human gammaherpresviruses in both EBV- and KSHV-infected cells. Taken together, these results suggest that MHV-68 can be a useful tool to screen novel antiviral agents against human gammaherepsviruses and that angelicin may provide a lead structure for the development of antiviral drug against gammaherpesviruses.