• 作者：Apostolos P. Georgopoulos^a ; ^b ; ^c ; ^d ; ^e ; ^f ; ^{omega@umn.edu" class="auth_mail" title="E-mail the corresponding author} ; Lisa M. James^a ; ^d ; ^e ; Margaret Y. Mahan^a ; ^f ; Jasmine Joseph^a ; ^f ; Angeliki Georgopoulos^g ; ^h ; Brian E. Engdahl^a ; ^b ; ^e ; ⁱ
• 关键词：Gulf War Illness (GWI) ; Human Leukocyte Antigen (HLA) ; Genetic risk ; Veterans
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：3
• 期：Complete
• 页码：79-85
• 全文大小：435 K

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Differences in Human Leukocyte Antigen distinguished veterans with Gulf War Illness (GWI) from healthy Gulf War era veterans.

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Veterans with GWI show genetic susceptibility which is associated with increased severity of hallmark symptoms of GWI.

A large number of Gulf War veterans suffer from diffuse and debilitating symptoms that resemble altered immune functioning. This study evaluated whether the Human Leukocyte Antigen (HLA) gene, which is central to immune functioning, differs between veterans with GWI and unaffected Gulf War veterans. The findings highlight robust differences in HLA composition between the two groups and suggest that veterans with GWI are characterized by genetic susceptibility that confers risk for typical GWI symptoms. These findings provide compelling genetic evidence of immune dysfunction in GWI.