A current perspective on the role for molecular studies in soft tissue tumor pathology

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• 作者：Angelo P. Dei Tos
• 关键词：Sarcoma ; Molecular genetics
• 刊名：Seminars in Diagnostic Pathology
• 出版年：November, 2013
• 年：2013
• 卷：30
• 期：4
• 页码：375-381
• 全文大小：5973 K

文摘

Soft tissue sarcomas represent an heterogenous group of malignancies. They represent a diagnostic challenge, and their accurate classification impact over treatment options. Sarcomas, similarly to hematologic neoplasm, often harbor relatively specific genetic aberrations, the recognition of which can be used to improved diagnostic accuracy. This review will focus on the clinical relevance of molecular analysis in soft tissue sarcomas, trying to elucidate its role as a diagnostic tool as well as a potential prognostic/predictive marker.