New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity
new diphenylmethane derivatives act as potent dual PPARα/γ partial agonists. docking explains the unusual lack of stereoselectivity for these compounds. these compounds exhibit strong activation of mitochondrial functions and biogenesis. they also show anti-proliferative effects only partly due to PPAR activity.