Infertility and recurrent miscarriage with complex II deficiency-dependent mitochondrial oxidative stress in animal models
详细信息 查看全文
- 作者：Takamasa Ishiia ; b ; ishiit@tokai.ac.jp" class="auth_mail" title="E-mail the corresponding author ; 1amfd001@is.icc.u-tokai.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Kayo Yasudaa ; c ; Masaki Miyazawad ; Junji Mitsushitae ; Thomas E. Johnsonf ; Phil S. Hartmang ; Naoaki Ishiia
- 关键词：ROS ; reactive oxygen species ; TCA ; tricarboxylic acid ; SDH ; succinate dehydrogease ; OXPHOS ; mitochondrial oxidative phosphorylation ; ETC ; electron transport chain ; ANT ; adenine nucleotide transporter ; SDHC ; succinate dehydrogenase C subunit ; ETF ; electron transferring flavoprotein ; CoQ ; ubiquinone ; CAD ; caspase activated DNase ; ICAD ; inhibitor of caspase activated DNase ; TNF ; tumor necrosis factor ; TNFR1 ; TNF receptor 1 ; TRAIL ; TNF-related apoptosis-inducible ligand ; DISC ; death-inducing signali
- 刊名：Mechanisms of Ageing and Development
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：155
- 期：Complete
- 页码：22-35
- 全文大小：3661 K
文摘
- •
SDHC mutation causes complex II deficiency-dependent oxidative stress in female reproductive organs, not male.
- •
The oxidative stress causes ovarian hemangiomas leading to abnormal follicle maturation.
- •
The oxidative stress does not affect spermatogenesis and early embryogenesis.
- •
The oxidative stress causes placental angiodysplasia and inflammation.
- •
The oxidative stress causes embryopathy and developmental arrest with excessive apoptosis.