Angiogenesis and Metabolism: Entwined for Therapy Resistance

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• 作者：Gabriela Jimé ; nez-Valerio¹ ; Oriol Casanovas¹ ; ^{ocasanovas@iconcologia.net}
• 关键词：angiogenesis ; antiangiogenic therapy ; antiangiogenic resistance ; hypoxia ; cancer metabolism ; metabolic symbiosis ; metabolic tumor adaptation ; mTOR.
• 刊名：Trends in Cancer
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：3
• 期：1
• 页码：10-18
• 全文大小：1692 K
• 卷排序：3

文摘

Angiogenesis and metabolism are entwined processes that permit tumor growth and progression. Blood vessel supply is necessary for tumor survival not only by providing oxygen and nutrients for anabolism but also by removing waste products from cellular metabolism. On the other hand, blocking angiogenesis with antiangiogenic therapies shows clinical benefits in treating several tumor types. Nevertheless, resistance to therapy emerges over time. In this review we discuss a novel mechanism of adaptive resistance involving metabolic adaptation of tumor cells, and we also provide examples of tumor adaptation to therapy, which may represent a new mechanism of resistance in several types of cancer. Thus, targeting this metabolic tumor adaptation could be a way to avoid resistance in cancer patients.