Anti-heparanase activity of ultra-low-molecular-weight heparin produced by physicochemical depolymerization
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- 作者：Oussama Achour ; Nicolas Poupard ; Nicolas Bridiau ; Stephanie Bordenave Juchereau ; Fredé ; ric Sannier ; Jean-Marie Piot ; Ingrid Fruitier Arnaudin ; Thierry Maugard ; tmaugard@univ-lr.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Heparin ; Ultrasonic-assisted radical hydrolysis ; Heparinase I-catalyzed 尾-elimination ; Glycol-split ; Heparanase ; Anti-angiogenesis
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：135
- 期：Complete
- 页码：316-323
- 全文大小：1057 K
文摘
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Production of ultrasonic Ultra Low Molecular Weight Heparin (usULMWH).
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Innovative ultrasonic assisted radical depolymerization of heparin produced usULMWH.
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usULMWH structure and biological activities were compared to others heparins.
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usULMWH have high anti-heparanase activity and moderate anticoagulant activities.
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usULMWH might be potential anti-angiogenic candidates for cancer therapy.