Chemical characterisation and the anti-inflammatory, anti-angiogenic and antibacterial properties of date fruit (Phoenix dactylifera L.)

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• 作者：Hajer Taleb^a ; Sarah E. Maddocks^b ; ^{smaddocks@cardiffmet.ac.uk} ; R. Keith Morris^b ; Ara D. Kanekanian^a
• 关键词：BCCAO ; Bilateral common carotid artery occlusion ; CD31 ; Cluster of differentiation 31 ; COX-2 ; Cycloxygenase-2 ; HBA ; Hydroxybenzoic acid ; HCA ; Hydroxycinnamic acids ; IL &minus ; 1 ; Interlukin &minus ; 1 ; IL &minus ; 1β ; Interlukin &minus ; 1 beta ; IL &minus ; 6 ; Interlukin &minus ; 6 ; LPS ; Lipopolysaccharide ; MIC ; Minimum inhibitory concentration ; ROS ; Reactive oxygen species ; TNF-α ; Tumour necrosis factor alpha ; VEGF ; Vascular endothelial growth factor
• 刊名：Journal of Ethnopharmacology
• 出版年：2016
• 出版时间：24 December 2016
• 年：2016
• 卷：194
• 期：Complete
• 页码：457-468
• 全文大小：763 K
• 卷排序：194

文摘

Date fruit, Phoenix dactylifera L. has traditionally been used as a medicine in many cultures for the treatment of a range of ailments such as stomach and intestinal disorders, fever, oedema, bronchitis and wound healing.Aim of the reviewThe present review aims to summarise the traditional use and application of P. dactylifera date fruit in different ethnomedical systems, additionally the botany and phytochemistry are identified. Critical evaluation of in vitro and in vitro studies examining date fruit in relation to anti-inflammatory, anti-angiogenic and antimicrobial activities are outlined.Key findingsThe ethnomedical use of P. dactylifera in the treatment of inflammatory disease has been previously identified and reported. Furthermore, date fruit and date fruit co-products such as date syrup are rich sources of polyphenols, anthocyanins, sterols and carotenoids. In vitro studies have demonstrated that date fruit exhibits antibacterial, anti-inflammatory and anti-angiogenic activity. The recent interest in the identification of the numerous health benefits of dates using in vitro and in vivo studies have confirmed that date fruit and date syrup have beneficial health effects that can be attributed to the presence of natural bioactive compounds.ConclusionsDate fruit and date syrup have therapeutic properties, which have the potential to be beneficial to health. However, more investigations are needed to quantify and validate these effects.