Chylomicrons: Advances in biology, pathology, laboratory testing, and therapeutics
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- 作者：Josep Julvea ; b ; c ; 1 ; jjulve@santpau.cat" class="auth_mail" title="E-mail the corresponding author ; Jesú ; s M. Martí ; n-Camposa ; b ; c ; 1 ; jmartinca@santpau.cat" class="auth_mail" title="E-mail the corresponding author ; Joan Carles Escolà ; -Gila ; b ; c ; Francisco Blanco-Vacaa ; b ; c ; d
- 关键词：ACAT ; acyl CoA acyl transferase ; Angptl3 ; angiopoietin-like protein 3 ; Angptl4 ; angiopoietin-like protein 4 ; Angptl8 ; angiopoietin-like protein 8 ; apo ; apolipoprotein ; apobec 1 ; apoB mRNA editing enzyme 1 ; CM ; chylomicron ; CMs ; chylomicrons ; COPII ; coat protein complex II ; DGAT ; diglyceride acyltransferase ; FABP ; fatty acid binding protein ; GLP-1 ; glucagon-like peptide-1 ; GPIHBP1 ; glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 ; HDL ; high-density lipoproteins ; HS
- 刊名：Clinica Chimica Acta
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：455
- 期：Complete
- 页码：134-148
- 全文大小：939 K
文摘
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Chylomicrons are large, triglyceride-rich lipoproteins formed in the intestine after a meal.
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Fasting healthy people have no chylomicrons in the blood serum.
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Most of monogenic diseases causing hyper- or hypochylomicronemia that can be diagnosed by clinical chemistry and genetic studies.
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Hyperchylomicronemia is a major risk factor of pancreatitis
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The first gene therapy approved in Europe is directed to LPL deficiency, the main cause of type I hyperlipidemia.