iTRAQ technology-based identification of human peripheral serum proteins associated with depression
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- 作者：Q. Wanga ; X. Sua ; X. Jiangb ; X. Donga ; Y. Fana ; J. Zhanga ; C. Yua ; W. Gaoc ; S. Shia ; J. Jianga ; W. Jiangb ; T. Weia ; hydwtm@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANGPTL3 ; angiopoietin-like 3 ; CRP ; c-reaction protein ; CSF ; cerebrospinal fluid ; EDTA ; ethylenediaminetetraacetic acid ; ELISA ; enzyme-linked immuno sorbent assay ; FDR ; false discovery rate ; HAM-D-17 ; 17-item Hamilton Rating Scale for Depression ; IPA ; ingenuity pathway analysis ; ITIH4 ; inter-alpha-trypsin inhibitor heavy chain H4 ; iTRAQ ; isobaric tag for relative and absolute quantitation ; LC&ndash ; MS/MS ; liquid chromatography&ndash ; tandem mass spectrometry ; SAA1 ; serum amyloid A1 ; UPLC ; ultra-pe
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：25 August 2016
- 年：2016
- 卷：330
- 期：Complete
- 页码：291-325
- 全文大小：1358 K
文摘
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A proteomic study was developed to screen differentially expressed proteins in the peripheral serum of depressed patients.
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CRP, SAA1, ANGPTL3, ITIH4 were found to be up-regulated in the serum of depressed patients.
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This study highlights putative disease biomarkers for depression.