Angiopoietin-like protein 8 (betatrophin) is a stress-response protein that down-regulates expression of adipocyte triglyceride lipase
详细信息 查看全文
- 作者：Yuan Zhanga ; b ; 1 ; Shiwu Lia ; 1 ; William Donelana ; Chao Xiea ; Hai Wanga ; Qi Wub ; Daniel L. Purichc ; Westley H. Reevesd ; Dongqi Tangb ; tangdq@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Li-Jun Yanga ; yanglj@pathology.ufl.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANGPTL8 ; Betatrophin ; Stress protein ; Histidine deprivation ; ATGL
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：1861
- 期：2
- 页码：130-137
- 全文大小：1040 K
文摘
- •
ANGPTL8 is a stress-response protein.
- •
RAS/c-RAF/MAPK signaling pathway mediates ANGPTL8 transcription.
- •
ANGPTL8 activates ERK signal transduction pathway.
- •
ANGPTL8 suppresses the expression of ATGL via up-regulating Egr1expression.