Angiotensin I-converting enzyme-inhibitory peptides from bovine collagen: insights into inhibitory mechanism and transepithelial transport
详细信息 查看全文
- 作者：Yu Fua ; Jette Feveile Younga ; Martin Krø ; yer Rasmussena ; Trine Kastrup Dalsgaarda ; René ; Lametschb ; Rotimi E. Alukoc ; Margrethe Therkildsena ; margrethe.therkildsen@food.au.dk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Collagen peptides ; angiotensin I-converting enzyme ; digestive enzymes ; non-competitive inhibition ; molecular docking ; transepithelial transport
- 刊名：Food Research International
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：89
- 期：part_P1
- 页码：373-381
- 全文大小：861 K
文摘
- •
A novel collagen-derived ACE-inhibitory peptide was identified.
- •
VGPV and GPRGF remained stable towards digestive enzymes.
- •
Collagen-derived ACE-inhibitory peptides were non-competitive inhibitors.
- •
VGPV and GPRGF were transported across Caco-2 cell monolayers via the paracellular pathway.