Implications of MDSCs-targeting in lung cancer chemo-immunotherapeutics

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• 作者：Dickson Adah^a ; ^c ; ¹ ; Muzammal Hussain^b ; ^c ; ¹ ; Limei Qin^a ; Li Qin^a ; Jiancun Zhang^b ; Xiaoping Chen^a ; ^{chen_xiaoping@gibh.ac.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Ad ; adenoviral ; ARG ; arginase ; ATRA ; all-trans-retinoic acid ; CAIX ; carbonic anhydrase IX ; CDK ; cyclin-dependent kinase ; CTLs ; cytotoxic T lymphocytes ; DCs ; dendritic cells ; EGFR ; epidermal growth factor receptor ; G-CSF ; granulocyte colony-stimulating factor ; GM-CSF ; granulocyte monocyte colony stimulating factor ; ICTIs ; inflammatory cellular tumor infiltrates ; IL ; interleukin ; IL-2Rβ ; IL-2 receptor beta ; iNOS ; inducible nitric oxide synthase ; IFN-γ ; interferon gamma ; MDSCs ; myeloid-derived supp
• 刊名：Pharmacological Research
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：110
• 期：Complete
• 页码：25-34
• 全文大小：1774 K

文摘

Despite advances in chemotherapy and immunotherapy, advanced lung cancer remains an incurable disease. Novel trends in anticancer therapeutics focus on harnessing the therapeutically-targeted tumor-related immune suppression. In this respect, myeloid-derived suppressor cells (MDSCs) have captured considerable attention in the last few years, as they are vividly implicated in tumor immune escape mechanisms. In this review, we specifically discuss the multifaceted roles of MDSCs in lung tumor microenvironment, encompassing lung tumor growth and progression via suppression of anti-tumor immunity, association with worse prognosis, and hampering the efficacy of lung cancer chemotherapy and immunotherapy. In addition, we also discuss that therapeutic manipulation of MDSCs-targeting, either alone or in combination with chemo- and/or immune-therapeutic regimens, may not only have tumor growth inhibition, anti-angiogenesis and anti-metastasis effects, but may also have the potential to enhance the efficacy of lung cancer chemotherapy and immunotherapy.