ALK and MYCN: When Two Oncogenes Are Better than One

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• 作者：Zhihui Liu¹ ; Carol  ; J. Thiele¹ ; ^{ct47a@nih.gov}
• 刊名：Cancer Cell
• 出版年：2012
• 出版时间：20 March, 2012
• 年：2012
• 卷：21
• 期：3
• 页码：325-326
• 全文大小：98 K

文摘

Mutations of ALK are frequently observed in MYCN-amplified neuroblastomas and correlate with poor clinical outcome, but how these oncogenes cooperate in neuroblastoma development remains unclear. In this issue of Cancer Cell, Zhu et?al. describe a mechanism by which ALK and MYCN synergistically induce neuroblastoma in the zebrafish model system.