Allopurinol reduces levels of urate and dopamine but not dopaminergic neurons in a dual pesticide model of Parkinson壮s disease
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- 作者：Anil Kachroo
- 关键词：Urate ; Parkinson壮s disease ; Allopurinol ; Paraquat ; Maneb
- 刊名：Brain Research
- 出版年：14 May 2014
- 年：2014
- 卷：1563
- 期：Complete
- 页码：103-109
- 全文大小：729 K
文摘
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Pharmacologically lowering serum and brain urate levels in mice using allopurinol.
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PQ+MB exposure produced significant motoric deficits not exacerbated by allopurinol.
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Dopamine content was reduced in mice only exposed to allopurinol and pesticides.
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PQ+MB decreased TH-positive nigral neurons not further exacerbated by allopurinol.