Tranilast stimulates endochondral ossification by upregulating SOX9 and RUNX2 promoters
详细信息    查看全文
文摘

SOX9 and RUNX2 sequentially regulate endochondral ossification.

An anti-allergic drug, tranilast, increases expression of Sox9 and Runx2.

Tranilast enhances expression of Col2a1, Acan, Col10a1, Mmp13, Pthrp, Ihh, and Axin2.

Tranilast increases matrix proteoglycans, alkaline phosphatase, and mineralization.

Tranilast is a potential agent that accelerates fracture repair.

© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号

地址:北京市海淀区学院路29号 邮编:100083

电话:办公室:(+86 10)66554848;文献借阅、咨询服务、科技查新:66554700