SOX9 and RUNX2 sequentially regulate endochondral ossification.
An anti-allergic drug, tranilast, increases expression of Sox9 and Runx2.
Tranilast enhances expression of Col2a1, Acan, Col10a1, Mmp13, Pthrp, Ihh, and Axin2.
Tranilast increases matrix proteoglycans, alkaline phosphatase, and mineralization.
Tranilast is a potential agent that accelerates fracture repair.