Procoagulant snake venoms have differential effects in animal plasmas: Implications for antivenom testing in animal models
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- 作者：Kalana P. Maduwagea ; b ; kalanapm@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Fiona E. Scorgiec ; Lisa F. Linczc ; Margaret A. O'Learya ; Geoffrey K. Isbistera ; b
- 刊名：Thrombosis Research
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：137
- 期：Complete
- 页码：174-177
- 全文大小：519 K
文摘
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Animals are used to test procoagulant venom toxicity and antivenom efficacy.
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Different animal plasmas have varying susceptibility to procoagulant venoms.
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Animal models are not appropriate to test procoagulant activity for human interventions.
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In vitro human plasma assays should be used to test procoagulant venoms.