Design of chondroitin sulfate-based polyelectrolyte nanoplexes: Formation of nanocarriers with chitosan and a case study of salmon calcitonin
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- 作者：Anita Umerskaa ; b ; umerskam@tcd.ie" class="auth_mail" title="E-mail the corresponding author ; Owen I. Corrigana ; ocorrign@tcd.ie" class="auth_mail" title="E-mail the corresponding author ; Lidia Tajbera ; lidia.tajber@tcd.ie" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chondroitin sulfate ; Chitosan ; Nanoparticles ; Polyelectrolyte complexes ; Calcitonin ; Peptide
- 刊名：Carbohydrate Polymers
- 出版年：2017
- 出版时间：20 January 2017
- 年：2017
- 卷：156
- 期：Complete
- 页码：276-284
- 全文大小：624 K
文摘
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Chondroitin/chitosan nanoparticles with/without calcitonin were characterized.
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Chondroitin sulfate can form binary complexes with calcitonin at the nanoscale.
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Properties of chondroitin nanoplexes depend on the medium.
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Media and composition of the nanoplexes affect the release of sCT.
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Chondroitin nanoplexes are promising carriers for biomedical applications.