Low expression of CysLT₁R and high expression of CysLT₂R mediate good prognosis in colorectal cancer

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• 作者：Cecilia Magnusson ; Maryna Mezhybovska ; Ester L&#xf6 ; rinc ; Eva Fernebro ; Mef Nilbert ; Anita Sj&#xf6 ; l ; er
• 关键词：CysLT₁R ; CysLT₂R ; β ; -Catenin ; Colorectal cancer
• 刊名：European Journal of Cancer
• 出版年：2010
• 出版时间：March 2010
• 年：2010
• 卷：46
• 期：4
• 页码：826-835
• 全文大小：1590 K

文摘

Colorectal cancer is the third most common cancer type in the Western world. In search of new treatment possibilities, the inflammation mediators, know as cysteinyl leukotrienes (CysLTs), have been shown to regulate intestinal epithelial cell survival and proliferation via the CysLT₁R, and cell differentiation via the CysLT₂R. These results prompted us to investigate the significance of CysLT₁R and CysLT₂R expression in colorectal cancer tissue for patient survival. The CysLT₁R, CysLT₂R, β-catenin and Bcl-xL protein expression levels were evaluated by immunohistochemistry in a tissue microarray of 329 colorectal patients. We found that high nuclear expression of CysLT₁R is associated with a poor prognosis, whereas high nuclear expression of CysLT₂R is associated with a good prognosis. We also observed that patients with colorectal tumours characterised by high CysLT₁R but low CysLT₂R nuclear expression had the lowest survival expectancy, whereas patients with colorectal tumours characterised by low CysLT₁R but high CysLT₂R nuclear expression had the best survival expectancy. Interestingly, β-catenin as a single prognostic marker did not exhibit any prognostic value. However, in patients with tumours characterised by a high CysLT₁R nuclear expression, an elevated β-catenin nuclear expression had a significantly prognostic value.

In conclusion these data indicate that nuclear expressions of CysLTRs are potential prognostic indicators of colorectal cancer.