Pilot Study to Assess Subjective and Objective Reporting of Potential Adverse Drug Reactions in Older Versus Younger HIV-Infected Patients Using Antiretroviral Therapy

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• 作者：Amy A. Hirsch ; Anita Compan ; Ren¨¦e H. Lawrence ; Janet M. Briggs ; Gopala K. Yadavalli ; Matthew A. Fuller
• 关键词：aging ; comorbidity ; HIV ; drug toxicity ; life span
• 刊名：Journal of the Association of Nurses in AIDS Care
• 出版年：2012
• 出版时间：September-October, 2012
• 年：2012
• 卷：23
• 期：5
• 页码：397-408
• 全文大小：226 K

文摘

Limited data exist on tolerability of antiretroviral therapy (ART) in older HIV-infected patients compared to their younger counterparts. There is also concern for overlap of ART toxicities with concomitant conditions potentially leading to an increased burden of ART-related adverse drug reactions (ADRs). A prospective, descriptive-comparative study was conducted to compare incidence and severity of ADRs secondary to ART in older (¡Ý50 years) versus younger (<50 years) HIV-infected patients. No differences were found in the presence or severity of subjective or objective ADRs between groups. The burden of intolerance appeared to be high for certain ADRs in both age groups. Regardless of age, subjects with certain concomitant illnesses had higher rates of potential ADRs. Providers need to be aware of patient characteristics that lead to increased rates of ART intolerance; for patients with?an increased comorbidity burden, providers need to be attentive to the potential impact on ART tolerability.