Irisin inhibition of growth hormone secretion in cultured tilapia pituitary cells

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• 作者：Anji Lian ; Xin Li ; Quan Jiang ; ^{jiangqua@gmail.com}
• 关键词：Irisin ; Growth hormone ; Tilapia ; Hepatocytes ; Pituitary cells
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：395-406
• 全文大小：1901 K
• 卷排序：439

文摘

Cloning of tilapia FNDC5 and examination of its tissue expression pattern. Production of recombinant irisin and confirmation of its biological activity. The antiserum produced was highly specific for tilapia irisin. Irisin inhibited GH gene expression and secretion in tilapia pituitary cells. Irisin reduced GH transcript expression via multiple signaling pathways.