Single-Cell Analysis Reveals a Close Relationship between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages

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• 作者：Nigel Kee¹ ; ² ; ^{nigel.kee@licr.ki.se} ; Nikolaos Volakakis¹ ; Agnete Kirkeby³ ; Lina Dahl¹ ; Helena Storvall¹ ; Sara Nolbrant³ ; Laura Lahti¹ ; Å ; sa K. Bjö ; rklund⁴ ; Linda Gillberg¹ ; Eliza Joodmardi¹ ; Rickard Sandberg¹ ; ² ; Malin Parmar³ ; Thomas Perlmann¹ ; ² ; ⁵ ; ^{thomas.perlmann@ki.se}
• 关键词：Parkinson&rsquo ; s disease ; development ; embryogenesis ; stem cell ; single cell RNA-seq ; dopamine ; subthalamic nucleus ; neurogenesis ; hypothalamus ; graph clustering
• 刊名：Cell Stem Cell
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：20
• 期：1
• 页码：29-40
• 全文大小：7356 K
• 卷排序：20

文摘

Single-cell RNA-seq can reconstruct Lmx1a+ neuronal development The Lmx1a+ population contains distinct mesDA and STN lineages The STN and mesDA lineages have related, yet distinct, transcription factor profiles Application of distinct markers can help optimize mesDA differentiation of hESCs