C4b-binding protein: The good, the bad and the deadly. Novel functions of an old friend
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- 作者：David Ermert David.Ermert@med.lu.se" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Anna M. Blom ; Anna.Blom@med.lu.se" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：aHUS ; atypical hemolytic uremic syndrome ; C3b ; activated complement factor 3 ; C4b ; activated complement factor 4 ; C4BP ; C4b-binding protein ; CCP ; complement control protein (domain) ; CRP ; C-reactive protein ; Gla ; γ-carboxyglutamic acid ; FH ; factor H ; FI ; factor I ; PS ; protein S
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：169
- 期：Complete
- 页码：82-92
- 全文大小：2643 K
文摘
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C4BP is a soluble complement inhibitor pivotal for body homeostasis.
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Mutations in C4BP are associated with aHUS and pregnancy loss.
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C4BP binding to dying cells and amyloid allows for their silent removal.
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Microbes binding C4BP are protected from complement attack and can cause infections.