- 作者：Roberto Bianchi ; Aless ; ra Gilardini ; Virginia Rodriguez-Menendez ; Norberto Oggioni ; Annalisa Canta ; Tina Colombo ; Giulia De Michele ; Sara Martone ; Aless ; ra Sfacteria ; Giuseppe Piedemonte ; et al.
- 关键词：Cisplatin ; Erythropoietin ; Peripheral neuropathy ; Tumour growth ; Neurophysiology ; Pathology ; Rat
- 刊名：European Journal of Cancer
- 出版年：2007
- 出版时间：March 2007
- 年：2007
- 卷：43
- 期：4
- 页码：710-717
- 全文大小：921 K
Rats received eight intraperitoneal (ip) injections of 2 mg/kg CDDP twice weekly. EPO co-administered (50 or 10 μg/kg ip, three times/week) had a dose-dependent effect, partially preventing CINP, but 0.5 μg/kg ip was not effective. The neuroprotective effect lasted at least 5 weeks after the last dose of EPO and CDDP. In addition, EPO (50 μg/kg ip three times/week) after the last injection of CDDP still induced a significant recovery of CINP.
In a separate experiment in rats bearing mammary carcinoma EPO treatment (50 μg/kg ip) given concurrently with CDDP (1.0 and 1.5 mg/kg twice a week for four weeks) was neuroprotective without influencing the effectiveness of the treatment or tumour growth. EPO thus appears to be an effective neuroprotectant that does not interfere with tumour treatment.