Numerical defect of circulating dendritic cell subsets and defective dendritic cell generation from monocytes of patients with advanced melanoma

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• 作者：Aless ; ra Failli ; Annalisa Legitimo ; Giulia Orsini ; Antonella Romanini ; Rita Consolini
• 关键词：Circulating dendritic cells ; Melanoma ; Generation of dendritic cells ; Immunotherapy
• 刊名：Cancer Letters
• 出版年：2013
• 出版时间：1 September, 2013
• 年：2013
• 卷：337
• 期：2
• 页码：184-192
• 全文大小：1123 K

文摘

The behaviour of circulating dendritic cells (DCs) and DC generation from monocytes in melanoma patients during the progression of disease have not been described.

We report a significant decrease in the absolute number of total DCs, which mainly affects plasmacytoid DCs in stage IV. Additionally, monocyte-DC generation is less efficient in advanced stages, resulting in DCs that exhibit increased phagocytic capacity, potentially indicating a less mature state. These findings elucidate aspects of basic tumour-mediated immunosuppression, which may have implications for immunotherapeutic approaches, suggesting that the selection of patients for immunotherapy should also be made on the basis of their immune status.