New and old roles of the peripheral and brain renin-angiotensin-aldosterone system (RAAS): Focus on cardiovascular and neurological diseases

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• 作者：A Mascolo^a ; ^{annamaria.mascolo@unina2.it} ; & M Sessa^a ; C Scavone^a ; A De Angelis^a ; C Vitale^b ; L Berrino^a ; F Rossi^a ; G Rosano^b ; ^c ; A Capuano^a
• 关键词：Pharmacology ; Angiotensin ; Renin&ndash ; angiotensin&ndash ; aldosterone system ; Heart failure ; Coronary artery disease ; Neurological diseases
• 刊名：International Journal of Cardiology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：227
• 期：Complete
• 页码：734-742
• 全文大小：601 K
• 卷排序：227

文摘

Brain RAAS could represent a new important therapeutic target to regulate cardiovascular and neurological diseases. Aminopeptidase type A inhibitors and angiotensin IV analogues are new drug classes acting on the brain RAAS. The development of compounds able to cross the blood-brain barrier is challenging due to the pharmacokinetic characteristics.