Intravenous ceftriaxone, followed by 12 or three months of oral treatment with trimethoprim-sulfamethoxazole in Whipple's disease

详细信息    查看全文

• 作者：Gerhard E. Feurle^a ; ^{g.e.feurle@t-online.de} ; Verena Moos^b ; Hendrik Blä ; ker^c ; Christoph Loddenkemper^d ; Annette Moter^e ; Andrea Stroux^f ; Thomas Marth^g ; Thomas Schneider^b
• 关键词：Whipple's disease ; Antibiotic treatment ; Ceftriaxone ; Trimethoprim-sulfamethoxazole ; Clinical trial
• 刊名：Journal of Infection
• 出版年：2013
• 出版时间：March, 2013
• 年：2013
• 卷：66
• 期：3
• 页码：263-270
• 全文大小：342 K

文摘

| Figures/TablesFigures/Tables | ReferencesReferences

Summary

Background

There is no agreement on how and for how long Whipple's disease should be treated. In a randomized trial it was shown that patients can be cured with ceftriaxone or meropenem followed by trimethoprim-sulfamethoxazole for 12 months. The present study tested whether trimethoprim-sulfamethoxazole for three months is sufficient.

Methods

In the time from July 2004 to July 2008, 40 untreated patients from central Europe were sequentially admitted to an open-label, non-randomized extension of the previous trial with essentially an identical protocol. The modified treatment consisted of 2?g ceftriaxone intravenously once daily for 14 days followed by oral trimethoprim-sulfamethoxazole 160/800?mg twice daily for 3 months.

Primary endpoint was treatment efficacy compared with the previous study.

Results

Twelve months of treatment with trimethoprim-sulfamethoxazole was not more effective than 3?months?as indicated by clinical findings, laboratory (p?=?0.405, p?=?0.631, resp.), and histological data (p?=?0.456). 36 of 37 surviving patients including 14 with cerebrospinal infection were in remission without evidence of recurrence after a median follow-up time of 80 months. In one patient, Tropheryma whipplei arthritis recurred 63 months after initial therapy. Secondary endpoints indicate that histology of intestinal biopsies was a more useful indicator to determine eradication of T. whipplei than PCR. In submucosal and extra-intestinal tissue, the diagnostic value of the PCR was superior. Prospective data disclosed a heterogeneous spectrum of clinical presentation and course of Whipple's disease.

Conclusion

This study indicates that ceftriaxone followed by three months of trimethoprim-sulfamethoxazole is highly efficacious in the treatment of Whipple's disease.

Trial registration: ISRCTN45658456