GLP-1 and estrogen conjugate acts in the supramammillary nucleus to reduce food-reward and body weight
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- 作者：Heike Vogela ; f ; g ; Stefanie Wolfa ; f ; Cristina Rabasaa ; Francisca Rodriguez-Pachecoa ; Carina S. Babaeia ; Franziska Stö ; berc ; Jü ; rgen Goldschmidtc ; Richard D. DiMarchid ; Brian Finane ; g ; Matthias H. Tschö ; pe ; g ; Suzanne L. Dicksona ; Annette Schü ; rmannf ; g ; Karolina P. Skibickab ; Karolina.Skibicka@neuro.gu.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：Food reward ; GLP-1 ; Appetite ; Operant conditioning
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：110
- 期：part_PA
- 页码：396-406
- 全文大小：1754 K
文摘
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Estrogen (E) and GLP-1 interact to reduce body weight, food intake and food reward.
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This interaction can be localized to supramamillary nucleus (SUM), lateral hypothalamus (LH), and nucleus of the solitary tract (NTS).
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SUM underlies anorexic, weight loss, and reward effects of GLP-1 and E conjugate.
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LH underlies only the anorexic and body weight effects the GLP-1 and E conjugate.
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SUM is a novel brain area capable of exerting effects on energy balance and reward.