Annexin A2 is critical for blood-testis barrier integrity and spermatid disengagement in the mammalian testis

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• 作者：Katarzyna Chojnacka^a ; Barbara Bilinska^b ; Dolores D. Mruk^a ; ^{mruk@popcbr.rockefeller.edu}
• 关键词：Testis ; Sertoli cell ; Germ cell ; Cell junction ; Spermatogenesis
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1864
• 期：3
• 页码：527-545
• 全文大小：7479 K
• 卷排序：1864

文摘

Annexin A2 (ANXA2), an actin-binding protein, is mostly expressed by Sertoli cells. Anxa2 knockdown affects the ability of Sertoli cells to bundle/remodel F-actin microfilaments. Anxa2 knockdown disrupts the Sertoli cell permeability barrier in vitro and in vivo. Anxa2 knockdown results in tubulobulbar complex dysfunction and spermiation failure. Ectoplasmic specialization dynamics are not affected by Anxa2 knockdown.