Calcium channel blockers ameliorate iron overload-associated hepatic fibrosis by altering iron transport and stellate cell apoptosis
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- 作者：Ying Zhanga ; b ; c ; 1 ; Xin Zhaod ; 1 ; Yanzhong Change ; Yuanyuan Zhanga ; Xi Chuf ; Xuan Zhanga ; Zhenyi Liug ; Hui Guog ; Na Wangh ; Yonggang Gaoa ; Jianping Zhanga ; zhangjianping14@126.com" class="auth_mail" title="E-mail the corresponding author ; Li Chua ; i ; chuli0614@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CCB ; calcium channel blocker ; HSCs ; hepatic stellate cells ; DFO ; deferoxamine ; Tf ; transferrin ; TfR ; transmembrane transferrin receptor ; Ft ; ferritin ; LVDCCs ; L-type voltage-dependent calcium channels ; DMT-1 ; divalent metal transporter-1 ; ECM ; extracellular matrix ; Cont ; control ; Fe ; iron overload ; H-Ver ; high-dose verapamil ; L-Ver ; low-dose verapamil ; H-Nim ; high-dose nimodipine ; L-Nim ; low-dose nimodipine ; H-Dil ; high-dose diltiazem ; L-Dil ; low-dose diltiazem ; DMSO ; dimethyl sulfoxide ; FeSO4
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：15 June 2016
- 年：2016
- 卷：301
- 期：Complete
- 页码：50-60
- 全文大小：3022 K
文摘
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Calcium channel blockers (CCBs) reduced hepatic iron content.
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CCBs decreased hepatic fibrotic areas and collagen expression levels.
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CCBs resolve fibrosis by regulating iron transport and inhibiting HSC growth.