Novel mechanistic insights into treadmill exercise based rescue of social defeat-induced anxiety-like behavior and memory impairment in rats
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- 作者：Gaurav Patki ; Naimesh Solanki ; Fatin Atrooz ; Amber Ansari ; Farida Allam ; Brittany Jannise ; Jaganmohan Maturi ; Samina Salim ; ssalim@uh.edu" class="auth_mail
- 关键词：Physical exercise ; Anxiety ; Social defeat ; Cognition ; Oxidative stress
- 刊名：Physiology and Behavior
- 出版年：10 May 2014
- 年：2014
- 卷：130
- 期：Complete
- 页码：135-144
- 全文大小：960 K
文摘
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Social defeat stress-induced behavioral and cognitive impairments are rescued by moderate treadmill exercise.
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Moderate treadmill exercise suppresses social defeat-induced activation of oxidative stress and inflammation.
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Moderate treadmill via histone H3 acetylation/deacetylation dependent MeCP-2 activation regulates BDNF expression.