Economic Evaluation of Reamed versus Unreamed Intramedullary Nailing in Patients with Closed and Open Tibial Fractures: Results from the Study to Prospectively Evaluate Reamed Intramedullary Nails in Patients with Tibial Fractures (SPRINT)

详细信息    查看全文

• 作者：Matthias Briel ; MD ; MSc¹ ; ² ; Sheila Sprague ; MSc¹ ; Diane Heels-Ansdell ; MSc¹ ; Gordon Guyatt ; MD ; MSc¹ ; Mohit Bhandari ; MD ; MSc ; FRCSC¹ ; ³ ; ^{bhandam@mcmaster.ca} ; Gordon Blackhouse ; MSc¹ ; ⁴ ; David Sanders ; MD ; FRCSC⁵ ; Emil Schemitsch ; MD ; FRCSC⁶ ; Marc Swiontkowski ; MD⁷ ; Paul Tornetta III ; MD⁸ ; Stephen D. Walter ; PhD¹ ; Ron Goeree ; PhD¹ ; ⁴
• 关键词：cost-utility analysis ; economic analysis ; reamed intramedullary nails ; tibia fractures ; unreamed intramedullary nails
• 刊名：Value in Health
• 出版年：2011
• 出版时间：June 2011
• 年：2011
• 卷：14
• 期：4
• 页码：450-457
• 全文大小：513 K

文摘

Introduction

Recently, results from the large, randomized study to prospectively evaluate reamed intramedullary nails in patients with tibial fractures (SPRINT) trial suggested a benefit for reamed intramedullary nail insertion in patients with closed tibial shaft fractures largely based on cost-neutral autodynamizations and a potential advantage for unreamed intramedullary nailing in open fractures. We performed an economic evaluation to compare resource use and effectiveness of reamed and unreamed intramedullary nailing using a cost-utility analysis.

Methods

We calculated quality-adjusted life years (QALYs) for each patient from a self-administered health utility index 3 questionnaire for the first 12 months following the intramedullary nailing. A convenience sample of 235 SPRINT patients provided data on costs associated with health care resource utilization. All costs are reported in Canadian dollars for the 2008 financial year.

Results

We found incremental effects of ?.017 (95 % confidence interval [CI] ?.021?.058) and ?.002 (95 % CI ?.060?.062) QALYs for patients treated with reamed compared with unreamed intramedullary nails in closed and open fractures, respectively. The incremental costs for reamed compared with unreamed intramedullary nailing were $51 Canadian dollars (95 % CI ?2298?2400) in closed tibial fractures and $2546 Canadian dollars (95 % CI ?1773?6864) in open tibial fractures. Unreamed nailing dominated reamed nailing for both closed and open tibial fractures; however, the cost and the utility results had high variability.

Conclusion

Our economic analysis from a governmental perspective suggests small differences in both cost and effectiveness with large uncertainty between reamed and unreamed intramedullary nailing.