Effects of the benzodiazepine GABA_A α1-preferring antagonist 3-isopropoxy-β-carboline hydrochloride (3-ISOPBC) on alcohol seeking and self-administration in baboons

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• 作者：August F. Holtyn^a ; V.V.N. Phani Babu Tiruveedhula^b ; Michael Rajesh Stephen^b ; James M. Cook^b ; Elise M. Weerts^a ; ^{eweerts@jhmi.edu}
• 关键词：Alcohol ; 3-Isopropoxy-β-carboline hydrochloride ; 3-ISOPBC ; Self-administration ; Baboon
• 刊名：Drug and Alcohol Dependence
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：170
• 期：Complete
• 页码：25-31
• 全文大小：862 K
• 卷排序：170

文摘

Acute doses of 3-ISOPBC did not decrease alcohol seeking or consumption in baboons. Chronic doses of 3-ISOPBC reduced alcohol consumption. Chronic doses of 3-ISOPBC did not affect consumption of a non-alcoholic beverage. Effects of chronic doses of 3-ISOPBC on consumption were specific to alcohol.