Two short-acting kappa opioid receptor antagonists (zyklophin and LY2444296) exhibited different behavioral effects from the long-acting antagonist norbinaltorphimine in mouse anxiety tests
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- 作者：Peng Huanga ; Tatyana Yakovlevab ; Jane V. Aldrichb ; Julia Tunisa ; Christopher Parrya ; Lee-Yuan Liu-Chena ; lliuche@temple.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：5&prime ; -GNTI ; 5&prime ; -guanidinonaltrindole ; ANOVA ; analysis of variance ; AZ-ECPC ; ethyl 4-(3-carbamoylbenzyl)-1-(cyclohexylmethyl)piperidine-4-carboxylate ; AZ-MTAB ; 3-((1R ; 3r ; 5S)-8-((5-methylthiophen-2-yl)methyl)-8-azabicyclo[3.2.1]octan-3-yloxy)benzamide ; DOPR ; delta opioid receptor ; EPM ; elevated plus maze ; FST ; forced swim test ; i.p. ; intraperitoneal (ly) ; JDTic ; (3R)-7-hydroxy-N-[(2S)-1-[(3R ; 4R)-4-(3-hydroxyphenyl)-3 ; 4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl]-1 ; 2 ; 3 ; 4-tetrahydroisoquinol
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：26 February 2016
- 年：2016
- 卷：615
- 期：Complete
- 页码：15-20
- 全文大小：1169 K
文摘
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Short-acting KOPR antagonists (zyklophin and LY2444296) and long acting one (norBNI) showed similarities and differences in mouse anxiety tests.
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They all exhibited anxiolytic-like effects in the NIH test.
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However, the long-acting KOPR antagonist, but not the short-acting ones, displayed anti-anxiety effect in the EPM test.