Synthesis and pharmacological evaluation of new biphenylic derivatives as CB2 receptor ligands
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- 作者：Simone Bertinia ; 1 ; simone.bertini@unipi.it" class="auth_mail" title="E-mail the corresponding author ; Andrea Chiccab ; 1 ; Chiara Arenaa ; b ; Stefano Chiccab ; Giuseppe Saccomannia ; Jü ; rg Gertschb ; Clementina Maneraa ; Marco Macchiaa
- 关键词：CB2 ; Cannabinoid receptor ; Biphenyl-carboxamides ; CB2 agonist ; CB2 antagonist ; CB2 inverse agonist ; Methylhonokiol ; Endocannabinoid system
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：30 June 2016
- 年：2016
- 卷：116
- 期：Complete
- 页码：252-266
- 全文大小：1043 K
文摘
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We synthesized 18 biphenylic carboxamides as new CB2-selective ligands.
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The functional activity is influenced by the substituent at position 4′ and 5.
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The methoxyl group at position 4′ is responsible for neutral antagonist behaviour.