Translational strategies for therapeutic development in nicotine addiction: Rethinking the conventional bench to bedside approach
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- 作者：Bernard Le Folla ; b ; c ; d ; e ; bernard.lefoll@camh.ca" class="auth_mail ; Abhiram Pushparaja ; Yaroslaw Pryslawskya ; Benoit Forgetf ; Kiran Vemurig ; h ; i ; Alexandros Makriyannisg ; h ; i ; Jose M. Trigoa
- 关键词：伪4尾2 ; ALPHA-4 beta-2 nicotinic receptor ; 尾2 ; nicotinic receptor subunit ; AM251 ; inverse agonist at the CB1 cannabinoid receptor ; AM4113 ; CB1 putative neutral antagonist ; BOLD ; blood&ndash ; oxygen-level dependent ; cAMP ; Cyclic Adenosine Monophosphate ; CB1 ; cannabinoid receptor type 1 ; CB2 ; cannabinoid receptor type 2 ; CPP ; conditioned place preference ; DBS ; deep brain stimulation ; EU ; European Union ; FDA ; Food and Drug Administration ; fMRI ; functional magnetic resonance imaging ; GABA ; gamma-aminob
- 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
- 出版年：3 July 2014
- 年：2014
- 卷：52
- 期：Complete
- 页码：86-93
- 全文大小：565 K
文摘
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Smoking cessation medications present a high rate of relapse after quit attempts.
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‘bench to bedside’ CB1 based strategy for nicotine showed serious side effects.
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Current pre-clinical models want to eliminate unwanted side effects.
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‘bed side to bench strategy’ studied the role of the insula in nicotine addiction.
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Limitations present on both models warrantee a future integrated approach.