A2A adenosine receptor antagonists to weaken the hypoxia-HIF-1α driven immunosuppression and improve immunotherapies of cancer
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- 作者：Stephen M Hatfield ; Michail Sitkovsky m.sitkovsky@neu.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Current Opinion in Pharmacology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：29
- 期：Complete
- 页码：90-96
- 全文大小：550 K
文摘
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A2AR and hypoxia in TME are important barriers that must be overcome in cancer immunotherapy.
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A2AR on immune cells are critical and non-redundant mediators of physiological immunosuppression.
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Blocking immunosuppressive A2AR-mediated signaling may improve current cancer immunotherapy.