Participation of peripheral TRPV1, TRPV4, TRPA1 and ASIC in a magnesium sulfate-induced local pain model in rat
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- 作者：Dragana Srebro ; srebrodragana1@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Sonja Vučković ; Milica Prostran
- 关键词：[d ; (g)] ; difference in pressures ; AA% ; analgesic activity ; AITC ; allyl isothiocyanate ; ANOVA ; analysis of variance ; ASIC ; acid-ion sensing channel ; MS ; magnesium sulfate ; NMDA ; N-methyl-d-aspartate receptors ; NO ; nitric oxide ; PWT ; paw withdrawal threshold ; TRP ; transient receptor potential ; TRPA1 ; ankyrin 1 ; TRPM ; TRP melastatin types 6 and 7 ; TRPV1 ; vanilloid 1 ; TRPV4 ; vanilloid 4
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：17 December 2016
- 年：2016
- 卷：339
- 期：Complete
- 页码：1-11
- 全文大小：1192 K
文摘
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Subcutaneous injection of isotonic solution of magnesium sulfate (MS) produces local pain.
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MS modulates the activity of TRPV1, TRPV4, TRPA1 and ASICs.
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ASIC is involved in the pronociceptive effect of pH-unadjusted, but not pH-adjusted MS solution.
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TRPV1, TRPV4 and TRPA1 antagonists might be used for local treatment of injection-related pain.