GSK3尾 and Gli3 play a role in activation of Hedgehog-Gli pathway in human colon cancer 鈥?Targeting GSK3尾 downregulates the signaling pathway and reduces cell proliferation
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- 作者：Diana Trnskia ; diana.trnski@irb.hr" class="auth_mail" title="E-mail the corresponding author ; Maja Sabola ; maja.sabol@irb.hr" class="auth_mail" title="E-mail the corresponding author ; Ante Gojevi膰b ; ante.gojevic@xnet.hr" class="auth_mail" title="E-mail the corresponding author ; Marina Martini膰a ; marina.martinic.87@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Petar Ozreti膰a ; pozretic@irb.hr" class="auth_mail" title="E-mail the corresponding author ; Vesna Musania ; vmusani@irb.hr" class="auth_mail" title="E-mail the corresponding author ; Snje啪ana Rami膰c ; snjezana.ramic@zg.t-com.hr" class="auth_mail" title="E-mail the corresponding author ; Sonja Levanata ; levanat@irb.hr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hedgehog signaling ; Gli3 ; GSK3尾 ; Autophagy ; Apoptosis ; Colon cancer
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：1852
- 期：12
- 页码：2574-2584
- 全文大小：2305 K
文摘
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GSK3尾 staining in colon cancer tissues is positively correlated with DUKES' stage.
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GSK3尾 is the main molecular switch for Hh-Gli activation in colon cancer cells.
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GSK3尾 inhibition with LiCl enhances Gli3 processing.
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GSK3尾 inhibition with LiCl downregulates Hh-Gli signaling and induces cell death.
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Hh-Gli signaling stimulation rescues LiCl effects on cell proliferation.