Respiratory compliance in preterm infants after a single rescue course of antenatal steroids: a randomized controlled trial

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• 作者：Cindy McEvoy ; Diane Schilling ; Dawn Peters ; Carrie Tillotson ; Patricia Spitale ; Linda Wallen ; Sally Segel ; Susan Bowling ; Michael Gravett ; Manuel Dur
• 关键词：Betamethasone ; functional residual capacity ; premature infants ; pulmonary function ; rescue antenatal corticosteroids ; respiratory compliance
• 刊名：American Journal of Obstetrics and Gynecology
• 出版年：2010
• 出版时间：June 2010
• 年：2010
• 卷：202
• 期：6
• 页码：544.e1-544.e9
• 全文大小：350 K

文摘

Objective

To compare respiratory compliance and functional residual capacity in infants randomized to a rescue course of antenatal steroids vs placebo.

Study Design

Randomized, double-blinded trial. Pregnant women ≥14 days after initial antenatal steroids were randomized to rescue antenatal steroids or placebo. The primary outcomes were measurements of respiratory compliance and functional residual capacity. This study is registered with clinicaltrials.gov (NCT00669383).

Results

Forty-four mothers (56 infants) received rescue antenatal steroids and 41 mothers (57 infants) received placebo. There was no significant difference in birthweight, or head circumference. Infants in the rescue group had an increased respiratory compliance (1.21 vs 1.01 mL/cm H₂O/kg; adjusted 95 % confidence interval, 0.01-0.49; P = .0433) compared with placebo. 13 % in the rescue vs 29 % in the placebo group required ≥30 % oxygen (P < .05). Patients delivered at ≤34 weeks had greater pulmonary benefits.

Conclusion

Infants randomized to rescue antenatal steroids have a significantly increased respiratory compliance compared with placebo.