Sex-Linked period Genes in the Silkmoth, Antheraea pernyi: Implications for Circadian Clock Regulation and the Evolution of Sex Chromosomes

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• 作者：Anthony L Gotter ; Joel D Levine ; Steven M Reppert
• 刊名：Neuron
• 出版年：1999
• 出版时间：December 1999
• 年：1999
• 卷：24
• 期：4
• 页码：953-965
• 全文大小：595 K

文摘

Regulation of the period (per) gene is a critical feature of circadian clock function in insects. Here, we show that per is sex-linked in the silkmoth, Antheraea pernyi. The previously described silkmoth per gene is found on the Z chromosome. Silkmoth per is not dosage compensated at either the RNA or the protein level. Although earlier studies showed the presence of an oscillating endogenous antisense per transcript, we show that this transcript comes from a locus on the female-specific W chromosome. We further demonstrate the presence of a homolog of per on W that encodes a truncated protein. Rhythmicity of male (ZZ) moths demonstrates that neither of the W-linked per-like genes is essential for clock function. The presence of a per allele with duplications on W provides insight into the evolution of the sex chromosomes.