Resistance to the most common optic neuropathy is associated with systemic mitochondrial efficiency
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- 作者：Gerassimos Lascaratosa ; glascaratos@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Kai-Yin Chaub ; Haogang Zhuc ; Despoina Gkotsia ; Rosalind Kingb ; Ivan Goutd ; Deborah Kamala ; Philip J. Lutherta ; e ; Anthony H.V. Schapirab ; David F. Garway-Heatha
- 关键词：Neurodegeneration ; Glaucoma ; Intraocular pressure ; Mitochondria ; Ocular hypertension ; Normal tension glaucoma
- 刊名：Neurobiology of Disease
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：82
- 期：Complete
- 页码：78-85
- 全文大小：986 K
文摘
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Glaucomatous optic neuropathy is the commonest optic neuropathy.
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Its prevalence increases exponentially with ageing and raised intraocular pressure.
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We tested individuals that have not developed the neuropathy despite high pressure.
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They show more efficient mitochondria comparing to glaucoma patients and controls.
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This links systemic mitochondrial efficiency with resistance to neurodegeneration.