Richter's Transformation in the Era of Kinase Inhibitor Therapy: A Review

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• 作者：Emily C. Ayers ; Anthony R. Mato ; ^{Anthony.Mato@uphs.upenn.edu}
• 关键词：Chronic lymphocytic leukemia ; Diffuse large B-cell lymphoma ; KIs ; Non-Hodgkin lymphoma ; RT
• 刊名：Clinical Lymphoma Myeloma and Leukemia
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：17
• 期：1
• 页码：1-6
• 全文大小：206 K
• 卷排序：17

文摘

Richter's transformation (RT) is the transformation of chronic lymphocytic leukemia (CLL) into rapidly progressive B-cell lymphoma. This disease has long been recognized as a difficult-to-treat illness with poor survival outcomes. Although the incidence of RT has been well documented in previous studies, less is understood in the era of novel therapeutics, such as kinase inhibitors (KIs). The present review discusses the current risk factors, incidence, and outcomes of patients with RT in the modern era of KI therapy. Although the outcomes remain poor for RT patients after KI therapy, the most up-to-date studies have shown no increased incidence of RT in this patient population. Additionally, the present review reports the outcomes from the most recent data on novel therapies under investigation for patients with RT.