Age-related arterial telomere uncapping and senescence is greater in women compared with men
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- 作者：Ashley E. Walkera ; R. Garrett Morgana ; g ; Stephen J. Ivesa ; b ; c ; d ; Richard M. Cawthone ; Robert H.I. Andtbackaf ; Dirk Noyesf ; Lisa A. Lesniewskia ; b ; c ; Russell S. Richardsona ; b ; c ; Anthony J. Donatoa ; b ; c ; tony.donato@utah.edu" class="auth_mail" title="E-mail the corresponding author ;
- 关键词：BMI ; Body mass index ; BUN ; blood urea nitrogen ; ChIP ; Chromatin immunoprecipitation ; CVD ; cardiovascular disease ; hTERT ; telomerase ; p21 ; cyclin-dependent kinase inhibitor 1A ; p53 ; tumor suppressor p53 ; p-H2A.X ; phosphorylation of histone γ-H2A.X at serine 139
- 刊名：Experimental Gerontology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：73
- 期：Complete
- 页码：65-71
- 全文大小：318 K
文摘
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Arterial telomere uncapping and senescence are greater post-menopause in women.
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The effect of age on arterial telomere uncapping is greater in women than men.
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Mean arterial telomere length shortens with age similarly in women and men.
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There are sex differences in which clinical features relate to telomere dysfunction.