Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle
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- 作者：Eija Pirinen1 ; 2 ; 3 ; Carles Cantó ; 4 ; carlos.cantoalvarez@rd.nestle.com" class="auth_mail ; Young Suk Jo1 ; Laia Morato1 ; 5 ; 6 ; Hongbo Zhang1 ; Keir J. Menzies1 ; Evan G. Williams1 ; Laurent Mouchiroud1 ; Norman Moullan1 ; Carolina Hagberg1 ; 7 ; Wei Li8 ; Silvie Timmers1 ; 9 ; Ralph Imhof10 ; Jef Verbeek1 ; 11 ; Aurora Pujol5 ; 6 ; Barbara van Loon10 ; Carlo Viscomi12 ; 13 ; Massimo Zeviani12 ; 13 ; Patrick Schrauwen9 ; Anthony A. Sauve8 ; Kristina Schoonjans14 ; Johan Auwerx1 ; admin.auwerx@epfl.ch" class="auth_mail
- 刊名：Cell Metabolism
- 出版年：3 June 2014
- 年：2014
- 卷：19
- 期：6
- 页码：1034-1041
- 全文大小：1725 K
文摘
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Inhibition of poly(ADP-ribose) polymerases (PARPs) enhances endurance performance
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Inhibition of PARPs improves mitochondrial function in skeletal muscle
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Parp-1 correlates with energy expenditure in heterogeneous mouse populations
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Genetic and acquired mitochondrial defects can be rescued by PARP inhibition